Int. J. Integ. Biol., 2009, 8(5): 1-6Wound healing activity of Cassia occidentalis L. in albino Wistar ratsSheeba M, Emmanuel S, Revathi K, Ignacimuthu SThe wound healing property of methanolic crude extract
of Cassia occidentalis L. leaves and a pure compound Chrysophanol
isolated from it was evaluated in excision, incision and dead space wound
models. The parameters studied included rate of wound contraction and the
period of epithelialization in excision wound model. Tensile strength in
incision wound model and granulation tissue dry weight in dead space model were
assessed along with histopathological
examinations. Chrysophanol was found to possess significant wound healing
property than methanol crude extract. This was evident by decrease in the
period of epithelialization, increase in the rate of wound contraction, skin
breaking strength, granulation tissue dry weight content and breaking strength
of granulation tissue. Histopathological study of the granulation tissue showed
increased collagenation when compared to control group of animals. C.occidentalis
can be a good source of wound healing compound.
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