Accumulated knowledge on genomic information, systems biology, and disease mechanisms provide an unprecedented opportunity to elucidate the genetic basis of diseases, and to discover novel therapeutic targets from genomic data. With hundreds to a few thousand potential targets available in the human genome alone, and the rise in the role of multi-drug therapies for complex diseases, there is an urgent need to understand the relationships between diseases and genes, and drugs and targets. These data will help inform and guide future drug discovery processes. Here, we present an update on targets with drugs available - their number, nature and interactions. We further elaborate on the network based approach for understanding the human 'disease 'ome' and the human 'druggome' taking diabetes as a case study.
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